Cerebral venous sinus thrombosis in childhood: clinical aspects and neurological and cognitive long-term outcome in three cases

被引:0
作者
G. Buccino
G. Cossu
A. De Fanti
C. Manotti
G. C. Izzi
D. Mancia
机构
[1] University of Parma,Department of Neuroscience, Section of Physiology
[2] Hospital of Parma,Division of Pediatrics
[3] Hospital of Parma,Centre for Haemostasis Disorders
[4] University of Parma,Department of Neuroscience, Section of Neurology
来源
Neurological Sciences | 2004年 / 25卷
关键词
Cerebral venous sinus thrombosis; Childhood; Long-term outcome; Cognitive assessment; Protein C deficiency;
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摘要
We report clinical findings, risk factors and neurological and cognitive long-term outcome in three Italian children aged 7, 8 and 5, respectively, who experienced cerebral venous sinus thrombosis (CVST). All children presented with headache, associated to nausea, vomiting and papilloedema. None suffered from epileptic seizures. In two of them a paresis of the sixth cranial nerve with diplopia was found. Diagnosis was confirmed by magnetic resonance imaging angiography (angio MRI) in all cases. In all patients plasma levels of protein C, protein S, antithrombin III (AT III), antiphospholipid antibodies (ApA) and homocysteine were detected. Furthermore, factor V Leiden mutation, prothrombin mutation G20210A and MTHFR mutation were searched for. A Protein C reduction was detected in all patients at onset; this finding, however, was not confirmed at follow-up in all of them. At one-year follow-up, neurological examination was normal in all children and neuropsychological assessment, aimed at excluding linguistic and non-linguistic cognitive deficits, revealed normal performances in two of them. In the third child, cognitive assessment confirmed a previously diagnosed developmental dyslexia.
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页码:296 / 300
页数:4
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