'The clocks that time us'—circadian rhythms in neurodegenerative disorders

被引：0
作者：
Aleksandar Videnovic
Alpar S. Lazar
Roger A. Barker
Sebastiaan Overeem
机构：
[1] Neurological Clinical Research Institute,Department of Neurology
[2] Massachusetts General Hospital,Department of Clinical Neurosciences
[3] Harvard Medical School,Department of Neurology
[4] University of Cambridge,undefined
[5] John van Geest Centre for Brain Repair,undefined
[6] Radboud University Medical Centre,undefined
来源：
Nature Reviews Neurology | 2014年 / 10卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Sleep and circadian disruption are common in Alzheimer disease, Parkinson disease and Huntington diseaseSymptoms of circadian disruption range from subjective sleep complaints and alterations of sleep timing to severe disruptions in rest–activity cycles and sleep architectureBehavioural, physiological and molecular markers of circadian system function suggest progressive deterioration of circadian rhythmicity as the disease progressesThe relationship between circadian dysfunction and neurodegenerative processes might be bidirectional: circadian dysfunction might exacerbate the disease processesBehavioural or pharmaceutical interventions that target sleep–wake cycles might reverse circadian disruption
引用
收藏
页码：683 / 693
页数：10
相关论文
共 389 条
[51]  
Van Someren EJ(1998)Inhibition of Alzheimer β-fibrillogenesis by melatonin J. Biol. Chem. 273 7185-7188
[52]  
Shea SA(2004)Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex J. Pineal Res. 36 224-231
[53]  
Scheer FA(2003)Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease J. Neurochem. 85 1101-1108
[54]  
Skene DJ(2003)Double blind study of melatonin effects on the sleep–wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia J. Nippon Med. Sch. 70 334-341
[55]  
Swaab DF(2010)Clinical aspects of melatonin intervention in Alzheimer's disease progression Curr. Neuropharmacol. 8 218-227
[56]  
Rosales-Corral SA(2008)Melatonin and bright-light treatment for rest–activity disruption in institutionalized patients with Alzheimer's disease J. Am. Geriatr Soc. 56 239-246
[57]  
Lin L(2007)Actigraphy in agitated patients with dementia. Monitoring treatment outcomes Z. Gerontol. Geriatr. 40 178-184
[58]  
Liu RY(2003)A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease Sleep 26 893-901
[59]  
Zhou JN(2009)Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease Am. J. Geriatr Psychiatry 17 166-169
[60]  
van Heerikhuize J(1999)A randomized, controlled trial of bright light therapy for agitated behaviors in dementia patients residing in long-term care Int. J. Geriatr Psychiatry 14 520-525
12345678910