'The clocks that time us'—circadian rhythms in neurodegenerative disorders

被引：0
作者：
Aleksandar Videnovic
Alpar S. Lazar
Roger A. Barker
Sebastiaan Overeem
机构：
[1] Neurological Clinical Research Institute,Department of Neurology
[2] Massachusetts General Hospital,Department of Clinical Neurosciences
[3] Harvard Medical School,Department of Neurology
[4] University of Cambridge,undefined
[5] John van Geest Centre for Brain Repair,undefined
[6] Radboud University Medical Centre,undefined
来源：
Nature Reviews Neurology | 2014年 / 10卷
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摘要：
Sleep and circadian disruption are common in Alzheimer disease, Parkinson disease and Huntington diseaseSymptoms of circadian disruption range from subjective sleep complaints and alterations of sleep timing to severe disruptions in rest–activity cycles and sleep architectureBehavioural, physiological and molecular markers of circadian system function suggest progressive deterioration of circadian rhythmicity as the disease progressesThe relationship between circadian dysfunction and neurodegenerative processes might be bidirectional: circadian dysfunction might exacerbate the disease processesBehavioural or pharmaceutical interventions that target sleep–wake cycles might reverse circadian disruption
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页码：683 / 693
页数：10
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