Chemical Constituents from Acanthopanax senticosus and Their Cytotoxic Activities

被引：0
|
作者：
Ying-Ying Wei
Peng Han
Jia-Qi Yue
Fan Li
机构：
[1] Huazhong University of Science & Technology,Department of Pharmacy, Tongji Hospital Affiliated to Tongji Medical College
[2] Huazhong University of Science & Technology,Department of Thoracic Surgery, Tongji Hospital affiliated to Tongji Medical College
来源：
Chemistry of Natural Compounds | 2022年 / 58卷
关键词：
Araliaceae; lignan; cytotoxicity; A549;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new lignan, named 1,6-bis-(3-methoxy-4-hydroxyphenyl)hexane-1,6-dione (1), together with seven known compounds (2–8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. Their structures were elucidated based on extensive spectroscopic analyses. All isolates were evaluated for in vitro cytotoxic activity against human cancer cells of HepG2, A549, HeLa, and MCF-7. Among them, compound 8 showed significant cytotoxic activity on HepG2 and MCF-7 cells with IC50 values of 10.9 ± 1.7 and 9.2 ± 1.5 μM, respectively.
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页码：610 / 613
页数：3
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