Enhanced Cortisol Response to Stress in Children in Autism

被引：0
|
作者：
Eve G. Spratt
Joyce S. Nicholas
Kathleen T. Brady
Laura A. Carpenter
Charles R. Hatcher
Kirk A. Meekins
Richard W. Furlanetto
Jane M. Charles
机构：
[1] Medical University of South Carolina,
[2] Nichols Institute-Quest Diagnostics,undefined
来源：
Journal of Autism and Developmental Disorders | 2012年 / 42卷
关键词：
Cortisol; Autism; Stress; HPA; Adaptability; Neurobiology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Children with Autism often show difficulties in adapting to change. Previous studies of cortisol, a neurobiologic stress hormone reflecting hypothalamic–pituitary–adrenal (HPA) axis activity, in children with autism have demonstrated variable results. This study measured cortisol levels in children with and without Autism: (1) at rest; (2) in a novel environment; and (3) in response to a blood draw stressor. A significantly higher serum cortisol response was found in the group of children with autism. Analysis showed significantly higher peak cortisol levels and prolonged duration and recovery of cortisol elevation following the blood-stick stressor in children with autism. This study suggests increased reactivity of the HPA axis to stress and novel stimuli in children with autism.
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页码：75 / 81
页数：6
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