Analgesic Activity of Hexaazaisowurtzitane Derivatives

被引：0
|
作者：
S. G. Krylova
T. N. Povet’eva
E. P. Zueva
N. I. Suslov
E. N. Amosova
T. G. Razina
K. A. Lopatina
O. Yu. Rybalkina
Yu. V. Nesterova
O. G. Afanas’eva
E. A. Kiseleva
S. V. Sysolyatin
D. A. Kulagina
V. V. Zhdanov
机构：
[1] Tomsk National Research Medical Center,E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
[2] Siberian Division of the Russian Academy of Sciences,Institute of Problems of Chemical and Energetic Technologies
来源：
Bulletin of Experimental Biology and Medicine | 2019年 / 166卷
关键词：
thiowurtzine; analgesic activity; somatogenic pain models;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pronounced analgesic activity of the innovative compound 4-(3,4-dibromthiophencarbonyl)-2,6,8,12-tetraacethyl-2,4,6,8,10,12hexaazatetracyclo[5,5,0,03, 11,05, 9] dodecane (thiowurtzine) was observed in the thermal nociceptive hot plate test and in the acute visceral and somatic deep pain model (acetic acid writhing test). In these experimental models, naloxone-sensitive thiowurtzine-induced analgesia was revealed. The absence of tropism to peripheral opioid receptors in the acetic acid writhing test was demonstrated using naloxone methiodide. Course administration of low-toxic thiowurtzine in effective doses was not associated with ulcerogenic damage to the gastric mucosa in experimental animals.
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页码：461 / 465
页数：4
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