Intracellular retention of thyroglobulin in the absence of the low-density lipoprotein receptor-associated protein (RAP) is likely due to premature binding to megalin in the biosynthetic pathway

[1] Bu G(2001)The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family Int Rev Cytol 209 79-116

[2] Willnow TE(1998)Receptor-associated protein (RAP): a specialized chaperone for endocytic receptors Biol Chem 379 1025-1031

[3] Marzolo MP(2011)New insights into the roles of megalin/LRP2 and the regulation of its functional expression Biol Res 44 89-105

[4] Farfán P(1995)Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo Proc Natl Acad Sci USA 92 4537-4541

[5] Willnow TE(1996)RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors EMBO J 15 2632-2639

[6] Armstrong SA(2000)Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules J Am Soc Nephrol 11 191-202

[7] Hammer RE(1999)Megalin (gp330) is an endocytic receptor for thyroglobulin on cultured fisher rat thyroid cells J Biol Chem 274 12898-12904

[8] Herz J(2006)TSH-Dependent expression of the LDL receptor-associated protein (RAP) in thyroid epithelial cells Thyroid 16 1097-1104

[9] Willnow TE(1994)Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/a2MR, and the receptor-associated protein (RAP) J Histochem Cytochem 42 531-542

[10] Rohlmann A(2000)Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells: a novel function in the control of thyroid hormone release J Biol Chem 275 7125-7138

[1] Bu G(2001)The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family Int Rev Cytol 209 79-116

[2] Willnow TE(1998)Receptor-associated protein (RAP): a specialized chaperone for endocytic receptors Biol Chem 379 1025-1031

[3] Marzolo MP(2011)New insights into the roles of megalin/LRP2 and the regulation of its functional expression Biol Res 44 89-105

[4] Farfán P(1995)Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo Proc Natl Acad Sci USA 92 4537-4541

[5] Willnow TE(1996)RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors EMBO J 15 2632-2639

[6] Armstrong SA(2000)Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules J Am Soc Nephrol 11 191-202

[7] Hammer RE(1999)Megalin (gp330) is an endocytic receptor for thyroglobulin on cultured fisher rat thyroid cells J Biol Chem 274 12898-12904

[8] Herz J(2006)TSH-Dependent expression of the LDL receptor-associated protein (RAP) in thyroid epithelial cells Thyroid 16 1097-1104

[9] Willnow TE(1994)Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/a2MR, and the receptor-associated protein (RAP) J Histochem Cytochem 42 531-542

[10] Rohlmann A(2000)Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells: a novel function in the control of thyroid hormone release J Biol Chem 275 7125-7138