Sesquiterpenoids from Farfugium japonicum and their inhibitory activity on NO production in RAW264.7 cells

被引：0
作者：
Jiang-He Zhao
Tong Shen
Xia Yang
Hong Zhao
Xia Li
Wei-Dong Xie
机构：
[1] Shandong University,Marine College
[2] Lanzhou Jiaotong University,Gansu Engineering Center of Botanical Pesticide, College of Chemistry and Bioengineering
来源：
Archives of Pharmacal Research | 2012年 / 35卷
关键词：
Sesquiterpenoid; Eremophilane; Lactone; Nitric oxide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new eremophilane sesquiterpenoid, namely, 3β-angeloyloxy-6β,8β-dihydroxy-9β-senecioyloxyeremophil-7(11)-en-12,8α-lactone, along with eight known sesquiterpenoids, was isolated from the rhizome of Farfugium japonicum. The structures of all isolates were identified based on analyses of spectroscopic data (HRESIMS, IR, 1D, and 2D NMR) and comparison with literature data. The inhibitory effects of compounds 1–4 on nitric oxide production in lipopolysaccaride-activated mouse macrophages were also evaluated.
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页码：1153 / 1158
页数：5
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