Unravelling mechanisms of p53-mediated tumour suppression

被引:0
|
作者
Kathryn T. Bieging
Stephano Spano Mello
Laura D. Attardi
机构
[1] Stanford University School of Medicine,Division of Radiation and Cancer Biology, Department of Radiation Oncology
[2] Stanford University School of Medicine,Department of Genetics
来源
Nature Reviews Cancer | 2014年 / 14卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
There are many cellular outcomes attributable to p53 activation, but identifying which of these, or which combination of these, is important for tumour suppression has remained challenging. As new roles for p53 emerge, this Opinion dissects the role of p53 in tumour suppression.
引用
收藏
页码:359 / 370
页数:11
相关论文
共 50 条
  • [1] Unravelling mechanisms of p53-mediated tumour suppression
    Bieging, Kathryn T.
    Mello, Stephano Spano
    Attardi, Laura D.
    NATURE REVIEWS CANCER, 2014, 14 (05) : 359 - 370
  • [2] Ferroptosis as a p53-mediated activity during tumour suppression
    Jiang, Le
    Kon, Ning
    Li, Tongyuan
    Wang, Shang-Jui
    Su, Tao
    Hibshoosh, Hanina
    Baer, Richard
    Gu, Wei
    NATURE, 2015, 520 (7545) : 57 - +
  • [3] Ferroptosis as a p53-mediated activity during tumour suppression
    Le Jiang
    Ning Kon
    Tongyuan Li
    Shang-Jui Wang
    Tao Su
    Hanina Hibshoosh
    Richard Baer
    Wei Gu
    Nature, 2015, 520 : 57 - 62
  • [4] Identifying novel mechanisms of p53-mediated tumor suppression
    Leisenring, Nathan H.
    Floyd, Robert W.
    Kirsch, David G.
    CANCER RESEARCH, 2019, 79 (13)
  • [5] Mechanisms of p53-mediated apoptosis
    Bates, S
    Vousden, KH
    CELLULAR AND MOLECULAR LIFE SCIENCES, 1999, 55 (01) : 28 - 37
  • [6] Mechanisms of p53-mediated apoptosis
    S. Bates
    K. H. Vousden
    Cellular and Molecular Life Sciences CMLS, 1999, 55 : 28 - 37
  • [7] Mechanisms of p53-mediated apoptosis
    Ding, HF
    Fisher, DE
    CRITICAL REVIEWS IN ONCOGENESIS, 1998, 9 (01): : 83 - 98
  • [8] Selective activation of p53-mediated tumour suppression in high-grade tumours
    Melissa R. Junttila
    Anthony N. Karnezis
    Daniel Garcia
    Francesc Madriles
    Roderik M. Kortlever
    Fanya Rostker
    Lamorna Brown Swigart
    David M. Pham
    Youngho Seo
    Gerard I. Evan
    Carla P. Martins
    Nature, 2010, 468 : 567 - 571
  • [9] The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
    Christophorou, M. A.
    Ringshausen, I.
    Finch, A. J.
    Swigart, L. Brown
    Evan, G. I.
    NATURE, 2006, 443 (7108) : 214 - 217
  • [10] Selective activation of p53-mediated tumour suppression in high-grade tumours
    Junttila, Melissa R.
    Karnezis, Anthony N.
    Garcia, Daniel
    Madriles, Francesc
    Kortlever, Roderik M.
    Rostker, Fanya
    Swigart, Lamorna Brown
    Pham, David M.
    Seo, Youngho
    Evan, Gerard I.
    Martins, Carla P.
    NATURE, 2010, 468 (7323) : 567 - U244