Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates

被引：0
作者：
Timothy J. Collier
Nicholas M. Kanaan
Jeffrey H. Kordower
机构：
[1] Michigan State University,Timothy J. Collier and Nicholas M. Kanaan are at the Division of Translational Science and Molecular Medicine
[2] Grand Rapids,Jeffrey H. Kordower is at the Department of Neurological Sciences
[3] Michigan 49503,undefined
[4] USA.,undefined
[5] Timothy J. Collier is also at the Center of Excellence in Parkinson's Disease Research,undefined
[6] Michigan State University,undefined
[7] Grand Rapids,undefined
[8] Michigan 49503,undefined
[9] USA.,undefined
[10] Rush University Medical Center,undefined
[11] Chicago,undefined
[12] Illinois 60612,undefined
[13] USA.,undefined
来源：
Nature Reviews Neuroscience | 2011年 / 12卷
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摘要：
Collieret al. revisit the idea that age-related and Parkinson's disease-related changes in midbrain dopamine neurons are unrelated. They review studies showing that markers of cellular risk factors accumulate with age in a pattern that mimics the pattern of degeneration seen in Parkinson's disease and propose that ageing induces a pre-parkinsonian state.
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页码：359 / 366
页数：7
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