The role of cytokines in the development of atherosclerosis

被引：0
作者：
A. R. Fatkhullina
I. O. Peshkova
E. K. Koltsova
机构：
[1] Fox Chase Cancer Center,
来源：
Biochemistry (Moscow) | 2016年 / 81卷
关键词：
cardiovascular diseases; atherosclerosis; inflammation; immune cells; adhesion molecules; cytokines;
D O I：
暂无
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学科分类号：
摘要：
Atherosclerosis contributes to the development of many cardiovascular diseases, which remain the leading cause of death in developed countries. Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries. It is caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a key factor at all stages of atherosclerosis progression. Cells involved in pathogenesis of atherosclerosis were shown to be activated by soluble factors, cytokines, that strongly influence the disease development. Pro-inflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. In this review, we discuss the latest findings on the role of cytokines in the development and progression of atherosclerosis.
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页码：1358 / 1370
页数：12
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