Comparison of the acylation of chitosan with succinic anhydride in aqueous suspension and in solution

被引：9

作者：

Golyshev, A. A. ^{[1
,2
]}

Moskalenko, Yu. E. ^{[2
,3
]}

Skorik, Yu. A. ^{[2
,4
]}

机构：

[1] St Petersburg State Chem Pharmaceut Acad, St Petersburg 197022, Russia

[2] Russian Acad Sci, Inst Macromol Cpds, 31 Bolshoi Prosp VO, St Petersburg 199004, Russia

[3] Tech Univ Darmstadt, D-64287 Darmstadt, Germany

[4] St Petersburg State Univ, Inst Chem, St Petersburg 198504, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2015年 / 64卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

chitosan; succinylchitosan; succinic anhydride; VITRO DRUG-RELEASE; ANTITUMOR-ACTIVITY; DELIVERY; NANOPARTICLES; DERIVATIVES; DOXORUBICIN; MICELLES; HYDROGEL;

D O I：

10.1007/s11172-015-0994-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A homogeneous reaction in 1% AcOH and a heterogeneous reaction in aqueous suspension were used to obtain N-succinylchitosan from chitosan and succinic anhydride. The H-1 NMR data indicated that both reactions resulted in selective acylation of the free amino group. Further experiments examined the effects of the main reaction parameters (temperature, reaction time, the ratio of the reagents, and chitosan preactivation) on the degree of succinylation of the product.

引用

页码：1168 / 1171

页数：4

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