Effects of inhaled corticosteroids on growth in asthmatic children

被引:4
作者
Creese K.H. [1 ]
Doull I.J.M. [1 ]
机构
[1] Cystic Fibrosis/Respiratory Unit, Department of Child Health, University Hospital of Wales, Cardiff
关键词
Asthma; Asthmatic Child; Budesonide; Fluticasone Propionate; Salmeterol;
D O I
10.1007/s11882-001-0079-2
中图分类号
学科分类号
摘要
This article presents a brief review of the effects of inhaled corticosteroids on growth in children with asthma. All currently available inhaled corticosteroids, where there is adequate data, have been shown to cause significant growth suppression in children in a dose-dependent manner. It is now apparent that there are differences in the growthsuppressive effects of different corticosteroids. Recent evidence confirms that the growth-suppressive effects are short lived and that, at conventional doses, inhaled corticosteroids do not affect final attained adult height. © 2001, Current Science Inc.
引用
收藏
页码:122 / 126
页数:4
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共 36 条
  • [1] Pierrepoint M.J., Doull I.J.M., Inflammation in asthma: the basis for rational therapy, Curr Paediatr, 10, pp. 145-149, (2000)
  • [2] Van Essen-Zandvliet E.E., Hughes M.D., Waalkens H.J., Et al., Effects of 22 months of treatment with inhaled corticosteroids and/or beta 2 agonists on lung function, airway responsiveness and symptoms in children with asthma, Am Rev Respir Dis, 146, pp. 547-554, (1992)
  • [3] Warner J.O., Review of prescribed treatment for children with asthma in 1990, BMJ, 311, pp. 663-666, (1995)
  • [4] Tinkelman D.G., Reed C.E., Nelson H.S., Offord K.P., Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children, Pediatrics, 92, pp. 64-77, (1993)
  • [5] Doull I.J.M., Freezer N.J., Holgate S.T., Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate, Am J Resp Crit Care Med, 151, pp. 1715-1719, (1995)
  • [6] Verberne A.A., Frost C., Roorda R.J., Et al., One year treatment with salmeterol compared with beclomethasone in children with asthma, Am J Resp Crit Care Med, 156, pp. 688-695, (1997)
  • [7] Simons F.E.R., A comparison of beclomethasone, salmeterol and placebo in children with asthma, N Engl J Med, 337, pp. 1659-1665, (1997)
  • [8] Allen D.B., Bronsky E.A., LaForce C.F., Et al., Growth in asthmatic children treated with fluticasone propionate, J Pediatr, 132, pp. 472-477, (1998)
  • [9] Long term effects of budesonide or nedocromil in children with asthma, N Engl J Med, 343, pp. 1054-1063, (2000)
  • [10] Cohen M.B., Welles R.R., Cohen S., Anthropometry in children: progress in allergic children as shown by increments in height, weight and maturity, Am J Dis Child, 60, pp. 1058-1066, (1940)