Preparation of the amphiphilic copolymer of poly(γ-benzyl L-glutamate)-g-poly(ethylene glycol) with different grafting ratio

被引：0
作者：
Jianhong Yi
Xiumiao Zhou
Guosheng Hu
Biaobing Wang
机构：
[1] North University of China,College of Materials Science and Engineering
[2] North University of China,Institute of Macromolecules and Bioengineering
来源：
Polymer Science Series B | 2010年 / 52卷
关键词：
Polymer Science Series; Graft Copolymer; AMPHIPHILIC Copolymer; PBLG; Molar Feed Ratio;
D O I：
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学科分类号：
摘要：
Poly(γ-benzyl L-glutamate)- g-poly(ethylene glycol) (PBLG-g- PEG) with different grafting ratio was prepared using P-toluenesulfonic acid as catalyst. The effect of the molecular weight of mono- methyl oligo(ethylene glycol), the molar feed ratio and reaction time on the grafting ratio was investigated. The micelles of PBLG-g-PEG were prepared by the dialysis method in deionized water. Transmission electron microscopy and dynamic light scatter studies showed that the micelles exhibited spherical morphologies and the diameter of the micelles was in the range of 50–200 nm. Clonazepam was loaded onto the core part of the micelles and drug-loading content and rele ase rate were dependent on the grafting ratio.
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页码：35 / 40
页数：5
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