Large Animal Models for Vascularized Composite Allotransplantation

被引：0
作者：
Woodall J.D. [1 ]
Schultz B.D. [1 ]
Sosin M. [1 ]
Barth R.N. [1 ]
机构：
[1] University of Maryland School of Medicine, 29 South Greene Street, Suite 200, Baltimore, 21201, MD
来源：
Current Transplantation Reports | 2014年 / 1卷 / 3期
关键词：
Canines; Chimerism; Composite tissue allotransplantation; Large animals; Nonhuman primate; Swine; Tolerance; Transplantation; Vascularized composite allograft;
D O I：
10.1007/s40472-014-0026-5
中图分类号：
学科分类号：
摘要：
Large animal models have served as the foundation for clinical trials in all solid organ transplantation. Likewise, pre-clinical studies in vascularized composite allotransplantation (VCA) have provided a foundation for initial human applications in VCA. The growth of clinical VCA correspondingly benefits from large animal studies investigating the unique immunobiology, improved immunosuppressive regimens, and the potential induction of immunologic tolerance. VCA studies in large animal models of nonhuman primates, swine, and canines have and continue to build knowledge towards improved clinical outcomes. © 2014, Springer International Publishing AG.
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页码：190 / 196
页数：6
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