A study on ascorbate inhibition of ceruloplasmin ferroxidase activity

被引：0
作者：
Rolf Arthur L¿vstad
机构：
[1] University of Oslo,Department of Medical Biochemistry
来源：
Biometals | 1997年 / 10卷
关键词：
ascorbate; ceruloplasmin; conalbumin; iron ions; transferrin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The ferroxidase activity of ceruloplasmin is often determined according to the method of Johnson et al. (1967), using apotransferrin for trapping ferric ions generated by the enzyme; spectrophotometrically monitoring the Fe–transferrin formation at pH6.0. Reports have shown that ascorbate inhibits this reaction, and it is hypothesized that the effect could be of physiological significance in individuals with a high ascorbate to ceruloplasmin ratio in plasma (e.g. premature babies).
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页码：123 / 126
页数：3
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