Umbilical cord blood transplantation

被引：4
作者：
Petropoulos D. [1 ]
Chan K.W. [1 ]
机构：
[1] Division of Pediatrics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030
来源：
Current Oncology Reports | 2005年 / 7卷 / 6期
关键词：
Cord Blood; Umbilical Cord Blood; Cord Blood Transplant; Cell Dose; Preparative Regimen;
D O I：
10.1007/s11912-005-0004-2
中图分类号：
学科分类号：
摘要：
Over the past decade umbilical cord blood has been established as a viable source of hematopoietic stem cell for allogeneic transplantation. Early experience with umbilical cord blood transplantation (CBT) demonstrated a lower incidence of graft-versus-host disease even though the procedure was performed with HLA-disparate grafts. The overall outcome of CBT appears similar to that of allogeneic bone marrow transplant. The expansion of the donor selection is particularly beneficial to ethnic minorities, whose representation in the marrow registries is relatively small. The major drawbacks of CBT are slow hematopoietic recovery and a high incidence of graft failure, as a result of a lower number of progenitors infused. This paper reviews the current results of CBT and ongoing investigations to increase its availability to a larger number of recipients. Copyright © 2005 by Current Science Inc.
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收藏
页码：406 / 409
页数：3
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  • [1] Rocha V., Wagner J.E., Sobocinski K., Et al., Comparison of graft-versus-host disease in children transplanted with HLA identical sibling umbilical cord blood versus HLA identical sibling bone marrow transplant, N. Engl. J. Med., 342, pp. 1846-1854, (2000)
  • [2] Rocha V., Cornish J., Sievers E., Et al., Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia, Blood, 97, pp. 2962-2971, (2001)
  • [3] Rubinstein F., Kurtzberg J., Loberiza F.R., Et al., Comparison of unrelated cord blood and unrelated bone marrow transplants for leukemia in children: A collaborative study of the New York Blood Center and the International Bone Marrow Transplant Registry, Blood, 98, (2001)
  • [4] Hurley C.K., Baxter Lowe L.A., Logan B., Et al., National Marrow Donor Program HLA-matching guidelines for unrelated marrow transplants, Biol. Blood Marrow Transplant., 9, pp. 610-615, (2003)
  • [5] Dalle J.H., Duval M., Moghrabi A., Et al., Results of an unrelated transplant search strategy using partially HLA-mismatched cord blood as an immediate alternative to HLA-matched bone marrow, Bone Marrow Transplant., 33, pp. 605-611, (2004)
  • [6] Gluckman E., Rocha V., Arcese W., Et al., Factors associated with outcomes of unrelated cord blood transplant: Guidelines for donor choice, Exp. Hematol., 32, pp. 397-407, (2004)
  • [7] Michel G., Rocha V., Chevret S., Et al., Unrelated cord blood transplantation for childhood acute myeloid leukemia: A Eurocord group analysis, Blood, 102, pp. 4290-4297, (2003)
  • [8] Gluckman E., Rocha V., Cord blood transplantation for children with acute leukemia: A Eurocord registry analysis, Blood Cells Mol. Dis., 33, pp. 271-273, (2004)
  • [9] Jacobsohn D.A., Hewlett B., Ranalli M., Et al., Outcomes of unrelated cord blood transplants and allogeneic-related hematopoietic stem cell transplants in children with high-risk acute lymphocytic leukemia, Bone Marrow Transplant., 34, pp. 901-907, (2004)
  • [10] Parikh S.H., Martin P.L., Szabolcs P., Et al., Outcomes of unrelated umbilical cord blood transplantation in pediatric patients with myelodysplastic syndrome, Biol. Blood Marrow Transplant., 11, SUPPL. 1, (2005)
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