Oral Chemotherapy in the Treatment of Hormone-Refractory Prostate Cancer

被引:0
作者
Kenneth J. Pienta
Jeffrey M. Kamradt
David C. Smith
机构
[1] The University of Michigan School of Medicine,The University of Michigan Comprehensive Cancer Center, Division of Hematology/Oncology, Department of Internal Medicine
来源
Drugs | 1999年 / 58卷
关键词
Prostate Cancer; Paclitaxel; Adis International Limited; Etoposide; Nuclear Matrix;
D O I
暂无
中图分类号
学科分类号
摘要
Oral chemotherapy has become a major component of the treatment of advanced prostate cancer. The recognition that prostate cancer grows very slowly and must be treated continuously with active agents has led to the development of several therapeutic regimens. These regimens employ oral agents such as estramustine, cyclophosphamide, and etoposide, as they can be taken on a daily basis at home by the patients. These regimens have demonstrated activity in patients with hormone-refractory prostate cancer; declines in both prostate specific antigen and soft tissue lesions have been demonstrated.
引用
收藏
页码:127 / 131
页数:4
相关论文
共 84 条
[21]  
Pienta KJ(1992)Potentiation by estramustine of the cytotoxic effect of vinblastine and doxorubicin in prostatic tumor cells J Clin Oncol 10 1754-61
[22]  
Redman BG(1992)Phase II study of estramustine and vinblastine, two microtubule inhibitors, in hormone refractory prostate cancer J Urol 147 931-4
[23]  
Walther PJ(1996)Estramustine and vinblastine: use of prostate specific antigen as a clinical trial endpoint for hormone refractory prostatic cancer Am J Clin Oncol 19 581-3
[24]  
Williams SD(1995)Symptomatic improvement associated with combined estramustine and vinblastine chemotherapy for metastatic prostate cancer New Engl J Med 332 1004-14
[25]  
Troner M(1987)Paclitaxel (Taxol) Prostate 11 95-106
[26]  
Scher HI(1993)Morphological studies on the effect of taxol on cultured human prostate cancer cells A phase II trial of the Eastern Cooperative Oncology Group. Cancer 72 2457-60
[27]  
Sternberg C(1992)Taxol in advanced, hormonerefractory carcinoma of the prostate Cancer Res 52 4433-40
[28]  
Heston WD(1996)Combined antimicrotubule activity of estramustine and taxol in human prostatic carcinoma cell lines Urology 48 164-70
[29]  
Nelson WG(1995)Effect of estramustine, etoposide and taxol on prostate cancer cell growth i Semin Oncol 22 41-5
[30]  
Liu LF(1997)v Proc Am Soc Clin Oncol 16 310A-8