A concise synthesis of benzimidazoles via the microwave-assisted one-pot batch reaction of amino acids up to a 10-g scale

被引：0
作者：
Pai Peng
Jin-Feng Xiong
Guang-Zhen Mo
Jia-Li Zheng
Ren-Hong Chen
Xiao-Yun Chen
Zhao-Yang Wang
机构：
[1] School of Chemistry and Environment,Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education
[2] South China Normal University,undefined
[3] Guangdong Food and Drug Vocational College,undefined
[4] Institute of Organic Chemistry,undefined
[5] RWTH Aachen University,undefined
来源：
Amino Acids | 2014年 / 46卷
关键词：
Benzimidazoles; One-pot synthesis; Amino acids; -Phenylenediamine; Microwave irradiation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An efficient method for the synthesis of aminomethyl benzimidazoles is developed by using a one-pot batch reaction between amino acids and o-phenylenediamines. This reaction proceeds smoothly in an unmodified household microwave oven, even though scale-up is to 10 g. A desirable method for the quick synthesis of benzimidazoles, which are used as a kind of important intermediates in drug synthesis, is provided by the scale-up utilization of amino acid resource.
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页码：2427 / 2433
页数：6
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