Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

被引：0
作者：
Javad Sharifi-Rad
Veronique Seidel
Michalak Izabela
Margalida Monserrat-Mequida
Antoni Sureda
Valeska Ormazabal
Felipe A. Zuniga
Shivaprasad Shetty Mangalpady
Raffaele Pezzani
Alibek Ydyrys
Gulmira Tussupbekova
Miquel Martorell
Daniela Calina
William C. Cho
机构：
[1] Universidad del Azuay,Facultad de Medicina
[2] University of Strathclyde,Natural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences
[3] Wroclaw University of Science and Technology,Department of Advanced Material Technologies, Faculty of Chemistry
[4] University of the Balearic Islands—IUNICS,Research Group in Community Nutrition and Oxidative Stress
[5] Health Research Institute of Balearic Islands (IdISBa),CIBER Fisiopatología de La Obesidad Y Nutrición (CIBEROBN)
[6] Instituto de Salud Carlos III (ISCIII),Department of Pharmacology, Faculty of Biological Sciences
[7] University of Concepción,Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy
[8] University of Concepción,Department of Chemistry
[9] NMAM Institute of Technology,Phytotherapy Lab, Endocrinology Unit, Department of Medicine (DIMED)
[10] University of Padova,Biomedical Research Centre
[11] AIROB,Department of Biophysics, Biomedicine and Neuroscience
[12] Associazione Italiana Per La Ricerca Oncologica Di Base,Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living
[13] Al-Farabi Kazakh National University,Department of Clinical Pharmacy
[14] The Elliott School of International Affairs,Department of Clinical Oncology
[15] Al-Farabi Kazakh National University,undefined
[16] University of Concepción,undefined
[17] Universidad de Concepción,undefined
[18] Unidad de Desarrollo Tecnológico,undefined
[19] UDT,undefined
[20] University of Medicine and Pharmacy of Craiova,undefined
[21] Queen Elizabeth Hospital,undefined
来源：
Cell Communication and Signaling | / 21卷
关键词：
Phenolic compounds; Cancer; Nrf2; Oxidative stress; Cytotoxicity; Apoptosis;
D O I：
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摘要：
Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors.
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