Insulin: An Emerging Treatment for Alzheimer’s Disease Dementia?

被引：0
作者：
Jill K. Morris
Jeffrey M. Burns
机构：
[1] University of Kansas Medical Center,Department of Neurology and Alzheimer’s Disease Center
[2] KU Medical Center Clinical Research Center,undefined
[3] Alzheimer’s Disease Center,undefined
来源：
Current Neurology and Neuroscience Reports | 2012年 / 12卷
关键词：
Insulin; Dementia; Alzheimer’s disease; Apolipoprotein E; Amyloid; Rosiglitazone; Pioglitazone; Insulin signaling; Cognition; Memory; Intranasal; Thiazolidinedione; Diabetes;
D O I：
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中图分类号：
学科分类号：
摘要：
Accumulating evidence indicates a role for metabolic dysfunction in the pathogenesis of Alzheimer’s disease (AD). It is widely reported that Type 2 diabetes (T2D) increases the risk of developing AD, and several postmortem analyses have found evidence of insulin resistance in the AD brain. Thus, insulin-based therapies have emerged as potential strategies to slow cognitive decline in AD. The main methods for targeting insulin to date have been intravenous insulin infusion, intranasal insulin administration, and use of insulin sensitizers. These methods have elicited variable results regarding improvement in cognitive function. This review will discuss the rationale for targeting insulin signaling to improve cognitive function in AD, the results of clinical studies that have targeted insulin signaling, and what these results mean for future studies of the role of insulin-based therapies for AD.
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页码：520 / 527
页数：7
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