Diabetes, microvascular pathology and Alzheimer disease

被引:0
作者
Raj N. Kalaria
机构
[1] Institute for Ageing and Health,
[2] Newcastle University,undefined
来源
Nature Reviews Neurology | 2009年 / 5卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Epidemiological studies suggest that the risk of developing cognitive impairment and dementia is increased in individuals with diabetes mellitus, although the evidence from clinicopathological studies on neurodegenerative changes is at odds with these observations. A thorough appraisal of concomitant vascular changes in dementia might resolve this incongruity.
引用
收藏
页码:305 / 306
页数:1
相关论文
共 25 条
[1]  
Sonnen JA(2009)Different patterns of cerebral injury in dementia with or without diabetes Arch. Neurol. 66 315-322
[2]  
Xu W. L.(2009)Uncontrolled diabetes increases the risk of Alzheimer’s disease: a population-based cohort study Diabetologia 52 1031-1039
[3]  
von Strauss E.(2009)β-Amyloid deposition in brains of subjects with diabetes Neuropathol. Appl. Neurobiol. 35 60-68
[4]  
Qiu C. X.(2004)Towards defining the neuropathological substrates of vascular dementia J. Neurol. Sci. 226 75-80
[5]  
Winblad B.(2006)Brain imaging in patients with diabetes: a systematic review Diabetes Care 29 2539-2548
[6]  
Fratiglioni L.(2008)Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology Neurology 71 750-757
[7]  
Alafuzoff I(2006)Diabetes is related to cerebral infarction but not to AD pathology in older persons Neurology 67 1960-1965
[8]  
Aho L(2002)Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study Diabetes 51 1256-1262
[9]  
Helisalmi S(2008)Anti-Aβ immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials J. Alzheimers Dis. 15 555-569
[10]  
Mannermaa A(2008)Human cerebral neuropathology of type 2 diabetes mellitus Biochim. Biophys. Acta 1792 454-469