Effects of moderate hypobaric hypoxic preconditioning on the expression of the transcription factors pCREB and NF-κB in the rat hippocampus before and after severe hypoxia

被引：6

作者：

Churilova A.V. ^{[1
]}

Rybnikova E.A. ^{[1
]}

Glushchenko T.S. ^{[1
]}

Tyulkova E.I. ^{[1
]}

Samoilov M.O. ^{[1
]}

机构：

[1] Laboratory for the Regulation of Brain Neuron Functions, Pavlov Institute of Physiology, St. Petersburg

来源：

Neuroscience and Behavioral Physiology | 2010年 / 40卷 / 8期

基金：

俄罗斯基础研究基金会;

关键词：

hippocampus; hypobaric hypoxia; neurons; preconditioning; transcription factors;

D O I：

10.1007/s11055-010-9340-2

中图分类号：

学科分类号：

摘要：

Preconditioning using three sessions of moderate hypobaric hypoxia, i.e., hypoxic preconditioning (HP), increased the tolerance of susceptible brain neurons to severe hypoxia and other harmful factors. The study addressed changes in the expression of transcription factors NF-κB (nuclear factor kappa B) and CREB (cAMP response element binding protein) in the hippocampus of rats preconditioned with moderate hypoxia. Immunocytochemical methods demonstrated that HP increased immunoreactivity for NF-κB and phosphorylated CREB (pCREB) in hippocampal fields CA1-CA4 and the dentate gyrus and promoted increases in the expression of these transcription factors in the hippocampus of preconditioned rats 3-24 h after severe hypobaric hypoxia. These data provide evidence that NF-κB and CREB are involved in the mechanisms forming HP-induced tolerance of the brain. © 2010 Springer Science+Business Media, Inc.

引用

页码：852 / 857

页数：5

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