Nitric oxide and blood pressure responses to short-term resistance training in adults with and without type-2 diabetes: a randomized controlled trial

被引：0
作者：
Sales M.M. [1 ]
de Sousa C.V. [2 ]
de Paula Santana H.A. [3 ]
Motta-Santos D. [4 ]
Barbosa L.P. [2 ]
Santos P.A. [2 ]
Rezende T.M.B. [5 ]
Browne R.A.V. [6 ]
de Andrade R.V. [5 ]
Simões H.G. [2 ]
机构：
[1] Department of Physical Education, State University of Goiás, Quirinópolis, GO
[2] Graduate Program in Physical Education, Catholic University of Brasília, Brasília, DF
[3] Department of Physical Education, Federal University of Mato Grosso do Sul, Campo Grande, MS
[4] Sports Department, Federal University of Minas Gerais, Belo Horizonte, MG
[5] Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, DF
[6] Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN
来源：
Sport Sciences for Health | 2018年 / 14卷 / 3期
关键词：
Diabetes mellitus; Exercise therapy; Hypertension; Strength training;
D O I：
10.1007/s11332-018-0468-8
中图分类号：
学科分类号：
摘要：
Background: Type-2 diabetes (T2D) is associated with endothelial dysfunction, increase in sympathetic tone and several cardiovascular disorders, such as systemic arterial hypertension and coronary artery disease. Aims: To determine the effects of resistance training (RT) on the responses of nitric oxide (NO) and blood pressure (BP) in individuals with T2D and their controls peers. Methods: Randomized controlled trial in which T2D patients and non-diabetic individuals (ND) performed 8 weeks of RT. Participants were 22 women and 12 men (age 62.3 ± 2.5 years) that were randomly allocated into four groups: T2D training (n = 9), ND training (n = 10), T2D control (n = 8), and ND control (n = 7). NO and BP were measured before and after the whole intervention. Results: There were no significant differences in nitrite concentrations between and within groups, with values varying between 1.22 ± 0.15 and 1.45 ± 0.13 Log µM. The T2D and ND experimental groups decreased systolic blood pressure (SBP) by 8.1 and 1.4 mmHg, respectively. However, the control groups showed elevation of SBP (3.6 mmHg for T2D and 4.1 mmHg for ND). Although none of these changes were significant (p > 0.05). In addition, T2D subjects who did not undergo the training increased diastolic blood pressure (p = 0.030) and mean arterial pressure (p = 0.054). Conclusions: Eight weeks of RT does not increase NO bioavailability, and in turn, does not reduce BP in T2D patients—though it prevented its increase. Trial registration: ensaiosclinicos.gov.br (ID: RBR-4d39z9). © 2018, Springer-Verlag Italia S.r.l., part of Springer Nature.
引用
收藏
页码：597 / 606
页数：9
相关论文
共 34 条
[1]  
Whiting D.R., Guariguata L., Weil C., Shaw J., IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030, Diabetes Res Clin Pract, 94, 3, pp. 311-321, (2011)
[2]  
American Diabetes A., 2. Classification and diagnosis of diabetes, Diabetes Care, 39, pp. S13-S22, (2016)
[3]  
Ding H., Triggle C.R., Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium, Vasc Health Risk Manag, 1, 1, pp. 55-71, (2005)
[4]  
Figueroa A., Baynard T., Fernhall B., Carhart R., Kanaley J.A., Endurance training improves post-exercise cardiac autonomic modulation in obese women with and without type 2 diabetes, Eur J Appl Physiol, 100, 4, pp. 437-444, (2007)
[5]  
Arauz-Pacheco C., Parrott M.A., Raskin P., American Diabetes A., Treatment of hypertension in adults with diabetes, Diabetes Care, 26, pp. S80-S82, (2003)
[6]  
Van de Veire N.R., De Winter O., Gir M., De Buyzere M., Van de Wiele C., De Sutter J., Fasting blood glucose levels are related to exercise capacity in patients with coronary artery disease, Am Heart J, 152, 3, pp. 486-492, (2006)
[7]  
Contreras F., Rivera M., Vasquez J., De la Parte M.A., Velasco M., Diabetes and hypertension physiopathology and therapeutics, J Hum Hypertens, 14, pp. S26-S31, (2000)
[8]  
Grossman E., Does increased oxidative stress cause hypertension?, Diabetes care, 31, pp. S185-S189, (2008)
[9]  
Guzel N.A., Hazar S., Erbas D., Effects of different resistance exercise protocols on nitric oxide, lipid peroxidation and creatine kinase activity in sedentary males, J Sports Sci Med, 6, 4, pp. 417-422, (2007)
[10]  
Simoes H.G., Asano R.Y., Sales M.M., Browne R.A., Arsa G., Motta-Santos D., Et al., Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition, PLoS One, 8, 11, (2013)
1234