New and Emerging Therapies for Short Bowel Syndrome in Children

被引：21
作者：
Jon A. Vanderhoof
Rosemary J. Young
Jon S. Thompson
机构：
[1] University of Nebraska Medical Center,Department of Pediatric Gastroenterology and Nutrition
[2] University of Nebraska Medical Center,Department of Surgery
[3] University of Nebraska Medical Center,985160 Nebraska Medical Center
来源：
Pediatric Drugs | 2003年 / 5卷 / 8期
关键词：
Parenteral Nutrition; Enteral Nutrition; Enteral Feeding; Short Bowel Syndrome; Bacterial Overgrowth;
D O I：
10.2165/00148581-200305080-00003
中图分类号：
学科分类号：
摘要：
This review provides an overview of traditional as well as emerging therapies useful in the management of pediatric short bowel syndrome. Pediatric short bowel syndrome is relatively uncommon; however, when it does occur, it presents a unique challenge to medical care providers. The use of parenteral and enterai nutrition to maximize growth and enhance intestinal adaptation so as to increase absorptive surface area has been the primary focus of therapy. In recent years, the advent of pharmacologic advances, including the use of antibacterial drugs, anti-motility drugs and hormonal therapies, has had a significant impact on this condition. At times, surgery may be indicated for dealing with complications, or providing alternative therapy such as transplantation. With ongoing research, it is likely that improved pharmacologic therapy will be available for enhanced intestinal adaptation, control of gut motility, treatment of small bowel bacterial overgrowth, and treatment of rejection following small intestinal transplantation.
引用
收藏
页码：525 / 531
页数：6
相关论文
共 90 条
[1]  
Nightingale JMD(1996)Gastrointestinal hormones in short bowel syndrome: peptide YY may be the “colonic brake” to gastric emptying Gut 39 267-72
[2]  
Kamm MA(2001)Nutritional and other postoperative management of neonates with short bowel syndrome correlates with clinical outcomes J Pediatr 139 5-7
[3]  
van der Sijp JRM(2001)Enteral nutrition in short bowel syndrome Semin Pediatr Surg 10 65-71
[4]  
Andorsky DJ(1998)Reducing parenteral requirement in children with short bowel syndrome: impact of an amino acid-based complete infant formula J Pediatr Gastroenterol Nutr 27 614-6
[5]  
Lund DP(1999)Short bowel syndrome: parenteral nutrition versus intestinal transplantation Ped Nutr ISPEN 1 8-15
[6]  
Lillehei CW(1998)Liver complications of pediatric parenteral nutrition: epidemiology Nutrition 14 153-7
[7]  
Vanderhoof JA(1997)Short bowel syndrome in children and adults Gastroenterology 113 1767-78
[8]  
Young RJ(1994)Effects of dietary menhaden oil on mucosal adaptation after small bowel resection in rats Gastroenterology 106 94-9
[9]  
Bines J(1995)A new treatment for patients with short bowel syndrome: growth hormone, glutamine, and a modified diet Ann Surg 222 243-54
[10]  
Francis D(1997)Effect of growth hormone, glutamine, and diet on adaptation in short-bowel syndrome: a randomized, controlled study Gastroenterology 113 1402-5
123456789