Synthesis and analgesic, anti-inflammatory activities of 3-(3-methoxyphenyl)-2-substituted amino-quinazolin-4(3H)-ones

被引：0
作者：
V. Alagarsamy
M. Gopinath
P. Parthiban
B. Subba Rao
K. Murali
V. Raja Solomon
机构：
[1] MNR College of Pharmacy,Medicinal Chemistry Research Laboratory
[2] Ratnam Institute of Pharmacy,Department of Pharmaceutical Chemistry
[3] C.L. Baid Metha College of Pharmacy,Department of Pharmaceutical Chemistry
[4] Central Drug Research Institute,Medicinal and Process Chemistry Division
来源：
Medicinal Chemistry Research | 2011年 / 20卷
关键词：
Quinazoline; Analgesic; Anti-inflammatory; Ulcer index;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A variety of novel 3-(3-methoxyphenyl)-2-substituted amino-quinazolin-4(3H)-ones were synthesized by reacting the amino group of 2-hydrazino-3-(3-methoxyphenyl)-quinazolin-4(3H)-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(3-methoxyphenyl)-quinazolin-4(3H)-one was synthesized from 3-methoxy aniline. The title compounds were investigated for analgesic, anti-inflammatory, and ulcerogenic behavior. Among these the compound 2-(1-methyl butylidene-hydrazino)-3-(3-methoxyphenyl)-3H-quinazolin-4-one (AS3) emerged as the most active compound for the analgesic activity, while the compound 2-(1-ethyl propylidene-hydrazino)-3-(3-methyoxyphenyl)-3H-quinazolin-4-one (AS2) showed most potent anti-inflammatory activity of the series and these compounds are moderately more potent when compared to the reference standard diclofenac sodium. Interestingly the test compounds showed only mild ulcerogenic potential when compared to acetylsalicylic acid.
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页码：946 / 954
页数：8
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