c-Myc and AP4: a relay team for metabolic reprogramming of CD8+ T cells

被引:0
|
作者
Peer W F Karmaus
Hongbo Chi
机构
[1] St. Jude Children's Research Hospital,Peer W.F. Karmaus and Hongbo Chi are in the Department of Immunology
[2] Memphis,undefined
[3] Tennessee,undefined
[4] USA.,undefined
来源
Nature Immunology | 2014年 / 15卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
AP4, a transcription factor induced by the functionally related transcription factor c-Myc, maintains the cellular metabolic program for the sustained activation and population expansion of CD8+ T cells after the dynamic loss of c-Myc expression.
引用
收藏
页码:828 / 829
页数:1
相关论文
共 50 条
  • [11] The SWI/SNF canonical BAF complex and c-Myc cooperate to promote early fate decisions in CD8+ T cells
    Guo, Ao
    Huang, Hongling
    Zhu, Zhexin
    Chen, Mark J.
    Shi, Hao
    Sharma, Piyush
    Liedmann, Swantje
    Haydar, Dalia
    Yang, Mao
    Beere, Helen
    Krenciute, Giedre
    Roberts, Charles W. M.
    Chi, Hongbo
    Green, Douglas R.
    JOURNAL OF IMMUNOLOGY, 2022, 208 (01):
  • [12] Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1
    Jeng, Mark Y.
    Hull, Philip A.
    Fei, Mingjian
    Kwon, Hye-Sook
    Tsou, Chia-Lin
    Kasler, Herb
    Ng, Che-Ping
    Gordon, David E.
    Johnson, Jeffrey
    Krogan, Nevan
    Verdin, Eric
    Ott, Melanie
    JOURNAL OF EXPERIMENTAL MEDICINE, 2018, 215 (01): : 51 - 62
  • [13] Upregulation of CD4 on CD8+ T cells:: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells
    Sullivan, YB
    Landay, AL
    Zack, JA
    Kitchen, SG
    Al-Harthi, L
    IMMUNOLOGY, 2001, 103 (03) : 270 - 280
  • [14] Exploring the role of c-Myc in defining the fate of exhausted CD8 T cells
    Toumi, Ryma
    Deo, Rucha
    Bhise, Shruti
    Sarkar, Surojit
    Kalia, Vandana
    JOURNAL OF IMMUNOLOGY, 2022, 208 (01):
  • [15] c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity
    Dar, Asif A.
    Kim, Dale D.
    Gordon, Scott M.
    Klinzing, Kathleen
    Rosen, Siera
    Guha, Ipsita
    Porter, Nadia
    Ortega, Yohaniz
    Forsyth, Katherine S.
    Roof, Jennifer
    Fazelinia, Hossein
    Spruce, Lynn A.
    Eisenlohr, Laurence C.
    Behrens, Edward M.
    Oliver, Paula M.
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [16] c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity
    Asif A. Dar
    Dale D. Kim
    Scott M. Gordon
    Kathleen Klinzing
    Siera Rosen
    Ipsita Guha
    Nadia Porter
    Yohaniz Ortega
    Katherine S. Forsyth
    Jennifer Roof
    Hossein Fazelinia
    Lynn A. Spruce
    Laurence C. Eisenlohr
    Edward M. Behrens
    Paula M. Oliver
    Nature Communications, 14
  • [17] Mitochondrial C1qbp promotes differentiation of effector CD8+ T cells via metabolic-epigenetic reprogramming
    Zhai, Xingyuan
    Liu, Kai
    Fang, Hongkun
    Zhang, Quan
    Gao, Xianjun
    Liu, Fang
    Zhou, Shangshang
    Wang, Xinming
    Niu, Yujia
    Hong, Yazhen
    Lin, Shu-Hai
    Liu, Wen-Hsien
    Xiao, Changchun
    Li, Qiyuan
    Xiao, Nengming
    SCIENCE ADVANCES, 2021, 7 (49)
  • [18] Uncoupling protein 2 regulates metabolic reprogramming and fate of antigen-stimulated CD8+ T cells
    Leena Chaudhuri
    Rupesh K. Srivastava
    Ferdynand Kos
    Protul A. Shrikant
    Cancer Immunology, Immunotherapy, 2016, 65 : 869 - 874
  • [19] Heterogeneity of CD4+ and CD8+ T cells
    Woodland, DL
    Dutton, RW
    CURRENT OPINION IN IMMUNOLOGY, 2003, 15 (03) : 336 - 342
  • [20] The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation
    Prodinger, Johanna
    Loacker, Lisa J.
    Schmidt, Ralf L. J.
    Ratzinger, Franz
    Greiner, Georg
    Witzeneder, Nadine
    Hoermann, Gregor
    Jutz, Sabrina
    Pickl, Winfried F.
    Steinberger, Peter
    Marculescu, Rodrig
    Schmetterer, Klaus G.
    JOURNAL OF LEUKOCYTE BIOLOGY, 2016, 99 (04) : 583 - 594