Insulin plus metformin for T2DM—are there benefits?

被引:0
作者
Clifford J. Bailey
机构
[1] School of Life and Health Sciences,
[2] Aston University,undefined
[3] Gosta Green,undefined
来源
Nature Reviews Endocrinology | 2012年 / 8卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
When insulin therapy is introduced in advanced stages of type 2 diabetes mellitus many patients are already being treated with metformin and continue to receive this oral antihyperglycaemic agent. In a systematic review and meta-analysis, Hemmingsen et al. have evaluated the evidence for the benefits of this combination therapy.
引用
收藏
页码:449 / 450
页数:1
相关论文
共 16 条
  • [1] Inzucchi SE(2012)Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetologia 55 1577-1596
  • [2] Johnson JA(2005)Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with type 2 diabetes Diabetic Med. 22 497-502
  • [3] Simpson SH(2008)10-year follow-up of intensive glucose control in type 2 diabetes N. Engl. J. Med. 359 1577-1589
  • [4] Toth EL(2009)Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials. A position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association Diabetes Care 32 187-192
  • [5] Majumdar SR(2009)Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus Arch. Intern. Med. 169 616-625
  • [6] Holman RR(2009)AMPK: an emerging drug target for diabetes and the metabolic syndrome Cell Metab. 9 407-416
  • [7] Paul SK(2008)Metformin: effects on micro and macrovascular complications in type 2 diabetes Cardiovasc. Drugs Ther. 22 215-224
  • [8] Bethel MA(undefined)undefined undefined undefined undefined-undefined
  • [9] Matthews DR(undefined)undefined undefined undefined undefined-undefined
  • [10] Neil HA(undefined)undefined undefined undefined undefined-undefined