Synthesis and anti-inflammatory activity of ethynylthiazoles

被引：0
|
作者：
Geronikaki A. [1 ]
Vasilevsky S. [2 ]
Hadjipavlou-Litina D. [1 ]
Lagunin A. [1 ]
Poroikov B.V. [3 ]
机构：
[1] Aristotles University of Thessaloniki, School of Pharmacy
[2] Institute of Chemical Kinetics and Combustion, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk
[3] V. N. Orekhnovich Institute of Biomedical Chemistry, RAMS
来源：
Chemistry of Heterocyclic Compounds | 2006年 / 42卷 / 5期
关键词：
Anti-inflammatory; Ethynylthiazoles; Lipoxygenase (LOX);
D O I：
10.1007/s10593-006-0145-8
中图分类号：
学科分类号：
摘要：
A series of acetylene derivatives of thiazole using the Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity. Four compounds exhibited good anti-inflammatory activity and two inhibited soybean lipoxygenase. ©2006 Springer Science+Business Media, Inc.
引用
收藏
页码：675 / 680
页数：5
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