Synthesis and anti-inflammatory activity of ethynylthiazoles

被引：0

作者：

Geronikaki A. ^{[1
]}

Vasilevsky S. ^{[2
]}

Hadjipavlou-Litina D. ^{[1
]}

Lagunin A. ^{[1
]}

Poroikov B.V. ^{[3
]}

机构：

[1] Aristotles University of Thessaloniki, School of Pharmacy

[2] Institute of Chemical Kinetics and Combustion, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk

[3] V. N. Orekhnovich Institute of Biomedical Chemistry, RAMS

来源：

Chemistry of Heterocyclic Compounds | 2006年 / 42卷 / 5期

关键词：

Anti-inflammatory; Ethynylthiazoles; Lipoxygenase (LOX);

D O I：

10.1007/s10593-006-0145-8

中图分类号：

学科分类号：

摘要：

A series of acetylene derivatives of thiazole using the Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity. Four compounds exhibited good anti-inflammatory activity and two inhibited soybean lipoxygenase. ©2006 Springer Science+Business Media, Inc.

引用

页码：675 / 680

页数：5

共 19 条

[1]

Vane J.R., Botting R.M., Inflam. Res., 44, (1995)

[2]

Heller A., Koch T., Schmeck J., Ackern K., Drugs, 55, (1998)

[3]

Vasilevsky S.F., Tretyakov E.V., Elguero J., Adv. Heterocycl. Chem., 82, (2002)

[4]

Geronikaki A., Lagunin A., Poroikov V., Filimonov D., Hadjipavlou-Litina D., Vicini P., SAR and QSAR in Environmental Research, 13, (2002)

[5]

Srivastava P.K., Srivastava P.N., J. Med. Chem., 13, (1970)

[6]

Geronikaki A., Theophilidis G., Eur. J. Med. Chem., 27, (1992)

[7]

Vicini P., Amoretti L., Chiavarini M., Impicciatore M., Il Farmaco, 45, (1990)

[8]

Pignatello R., Mazzone S., Panico A.M., Mazzone G., Penissi G., Castano R., Matera M., Blandino G., Eur. J. Med.Chem., 26, (1991)

[9]

Raciti G., Mazzone P., Raudino A., Mazzone G., Cambria A., Bioorg. Med. Chem., 3, (1995)

[10]

Pumpor K., Windeisen E., Burger K., J. Heterocycl. Chem., 40, (2003)

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