NMDA Receptor Dependent Long-term Potentiation in Chronic Pain

被引：0
作者：
Xu-Hui Li
Hui-Hui Miao
Min Zhuo
机构：
[1] Xi’an Jiaotong University,Center for Neuron and Disease, Frontier Institute of Science and Technology
[2] University of Toronto,Department of Physiology, Faculty of Medicine
[3] University of Toronto,Department of Physiology, Faculty of Medicine
来源：
Neurochemical Research | 2019年 / 44卷
关键词：
NMDA receptor; Long-term potentiation; ACC; IC; Chronic pain; AC1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Since the discovery of NMDA receptor (NMDAR) dependent long-term potentiation (LTP) in the hippocampus, many studies have demonstrated that NMDAR dependent LTP exists throughout central synapses, including those involved in sensory transmission and perception. NMDAR LTP has been reported in spinal cord dorsal horn synapses, anterior cingulate cortex and insular cortex. Behavioral, genetic and pharmacological studies show that inhibiting or reducing NMDAR LTP produced analgesic effects in animal models of chronic pain. Investigation of signalling mechanisms for NMDAR LTP may provide novel targets for future treatment of chronic pain.
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页码：531 / 538
页数：7
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