Role of Gut Microbiome in Immune Regulation and Immune Checkpoint Therapy of Colorectal Cancer

被引：0
|
作者：
Linsen Shi
Yumei Xu
Min Feng
机构：
[1] The Affiliated Hospital of Xuzhou Medical University,Department of Gastrointestinal Surgery
[2] The Affiliated Hospital of Xuzhou Medical University,Department of Radiation Oncology Center
[3] The Affiliated Drum Tower Hospital of NanJing Medical University,Department of Gastrointestinal Surgery
来源：
Digestive Diseases and Sciences | 2023年 / 68卷
关键词：
Colorectal cancer; Gut microbiome; Immune regulation; Immune checkpoint therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignant tumors worldwide. Immune checkpoint therapies (ICTs) have been proven to be a reliable treatment for some subtypes of CRC. Gut microbiome is closely involved in intestinal carcinogenesis through the regulation of local immune and inflammation of colonic mucosa. Numerous studies have demonstrated that the immunotherapeutic efficacy of CRC and other kinds of cancer is influenced by the immunosuppressive microenvironment constituted by intestinal microbiome and their metabolites. This Review will discuss the recent advances in how gut microbiome can modify the immune microenvironment and its potential role in ICTs of CRC.
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页码：370 / 379
页数：9
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