Molecular mechanism of mitochondrial calcium uptake

被引:0
作者
Lele Wang
Xue Yang
Yuequan Shen
机构
[1] Nankai University,State Key Laboratory of Medicinal Chemical Biology
[2] Nankai University,College of Life Sciences
[3] Collaborative Innovation Center of Chemical Science and Engineering (Tianjin),undefined
来源
Cellular and Molecular Life Sciences | 2015年 / 72卷
关键词
Calcium signaling; Calcium channel; VDAC; MCU; MICU; EMRE; MCUR1;
D O I
暂无
中图分类号
学科分类号
摘要
Mitochondrial calcium uptake plays a critical role in various cellular functions. After half a century of extensive studies, the molecular components and important regulators of the mitochondrial calcium uptake complex have been identified. However, the mechanism by which these protein molecules interact with one another and coordinate to regulate calcium passage through mitochondrial membranes remains elusive. Here, we summarize recent progress in the structural and functional characterization of these important protein molecules, which are involved in mitochondrial calcium uptake. In particular, we focus on the current understanding of the molecular mechanism underlying calcium through two mitochondrial membranes. Additionally, we provide a new perspective for future directions in investigation and molecular intervention.
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页码:1489 / 1498
页数:9
相关论文
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