Development and Validation of an Analytical Method for the Detection and Quantification of Bromazepam, Clonazepam and Diazepam by UPLC-MS/MS in Surface Water

被引：0
作者：
Frederico Goytacazes de Araujo
Glauco Favilla Bauerfeldt
Marcia Marques
Eduardo Monteiro Martins
机构：
[1] UERJ,Post
[2] Rural Federal University of Rio de Janeiro (UFRRJ),Graduation Program in Chemistry (PPGQ)
[3] Rio de Janeiro State University (UERJ),Chemistry Institute
[4] Federal Institute of Espirito Santo (IFES),Department of Sanitary and Environmental Engineering
来源：
Bulletin of Environmental Contamination and Toxicology | 2019年 / 103卷
关键词：
PPCPs; Micropollutants; Surface waters; Benzodiazepines; UPLC-MS/MS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The development of analytical methods capable of determining micropollutants is essential for quality control of drinking water. Benzodiazepines, a class of pharmaceuticals with anxiolytic properties, have received increasing attention as micropollutants. The purpose of this study was to develop an analytical method for determination of three benzodiazepine drugs (bromazepam, clonazepam and diazepam) in surface water. For the extraction of the matrix analytes, SPE cartridges (C18, 500 mg/3 mL) were used. The method was validated according to the quality criteria of the USEPA 8000D Validation Guide. The developed and validated method showed recovery values between 57 and 100%, RSD < 20% and R2 > 0.9949. LD ranged between 2.70 and 5.00 ng L−1 for bromazepam and clonazepam respectively whereas LQ was 0.01 μg L−1 for all analytes. The matrix affected the signal intensity of clonazepam thus evidencing the matrix effect by analysis statistic (F test).
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页码：362 / 366
页数：4
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