Sequence patches on MAPK surfaces define protein-protein interactions

被引:0
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作者
Gary L Johnson
Shawn M Gomez
机构
[1] University of North Carolina School of Medicine,Department of Pharmacology and Lineberger Comprehensive Cancer Center
[2] University of North Carolina School of Medicine,Joint Department of Biomedical Engineering
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关键词
Sorbitol; Signaling Network; MAPK Cascade; Fus3 Activity; High Protein Expression;
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摘要
Recent studies on the modularity of mitogen-activated protein kinases show how redesigning 'surface patches' on a protein can change the topology of a signaling network.
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