Endothelial Dysfunction in Type 2 Diabetes Mellitus

被引：113

作者：

Dhananjayan R. ^{[1
]}

Koundinya K.S.S. ^{[2
]}

Malati T. ^{[3
]}

Kutala V.K. ^{[4
]}

机构：

[1] Department of Biochemistry, ACS Medical College & Hospital, Velappanchavadi, Chennai, Tamil Nadu

[2] Meenakshi Academy of Higher Education (University), Chennai, Tamil Nadu

[3] Department of Biochemistry, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana

[4] Department of Clinical Pharmacology and Therapeutics (Biochemistry), Nizam’s Institute of Medical Sciences, Hyderabad, Telangana

来源：

Indian Journal of Clinical Biochemistry | 2016年 / 31卷 / 4期

关键词：

Endothelial dysfunction; eNOS; IRS-1; Oxidative stress; Type 2 diabetes mellitus;

D O I：

10.1007/s12291-015-0516-y

中图分类号：

学科分类号：

摘要：

Endothelial dysfunction is an imbalance in the production of vasodilator factors and when this balance is disrupted, it predisposes the vasculature towards pro-thrombotic and pro-atherogenic effects. This results in vasoconstriction, leukocyte adherence, platelet activation, mitogenesis, pro-oxidation, impaired coagulation and nitric oxide production, vascular inflammation, atherosclerosis and thrombosis. Endothelial dysfunction is focussed as it is a potential contributor to the pathogenesis of vascular disease in diabetes mellitus. Under physiological conditions, there is a balanced release of endothelial-derived relaxing and contracting factors, but this delicate balance is altered in diabetes mellitus and atherosclerosis, thereby contributing to further progression of vascular and end-organ damage. This review focuses on endothelial dysfunction in atherosclerosis, insulin resistance, metabolic syndrome, oxidative stress associated with diabetes mellitus, markers and genetics that are implicated in endothelial dysfunction. © 2015, Association of Clinical Biochemists of India.

引用

页码：372 / 379

页数：7

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