Ultrasound-Induced Hyperthermia Increases Cellular Uptake and Cytotoxicity of P-Glycoprotein Substrates in Multi-Drug Resistant Cells

被引：0
作者：
Yang Liu
Cheong-Weon Cho
Xiangdong Yan
Thomas K. Henthorn
Kevin O. Lillehei
Wesley N. Cobb
Ka-yun Ng
机构：
[1] University of Colorado Health Sciences Center,Department of Pharmaceutical Sciences, School of Pharmacy
[2] University of Colorado Health Sciences Center,Department of Neurosurgery, School of Medicine
[3] University of Colorado Health Sciences Center,Department of Anesthesiology, School of Medicine
[4] University of Colorado Health Sciences Center,Department of Neurosurgery, School of Medicine
[5] University of Denver Research Institute,Department of Pharmaceutical Sciences, School of Pharmacy
[6] University of Colorado Health Sciences Center,undefined
来源：
Pharmaceutical Research | 2001年 / 18卷
关键词：
ultrasound; hyperthermia; multi-drug resistance; MDR; P-glycoprotein; P-glycoprotein modulating agents; verapamil; anticancer drugs;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. Localized hyperthermia has been shown previously to augment the cytotoxicity of some lipophilic anticancer drugs. Because many of the substrates for the multi-drug resistance (MDR) transporter P-glycoprotein (P-gp) are lipophilic in nature, studies were conducted to test the hypothesis that hyperthermia induced by ultrasound could also increase cellular uptake and cytotoxicity of P-gp substrates by P-gp-expressing cells.
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页码：1255 / 1261
页数：6
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