Ultrasound-Induced Hyperthermia Increases Cellular Uptake and Cytotoxicity of P-Glycoprotein Substrates in Multi-Drug Resistant Cells

被引：0

作者：

Yang Liu

Cheong-Weon Cho

Xiangdong Yan

Thomas K. Henthorn

Kevin O. Lillehei

Wesley N. Cobb

Ka-yun Ng

机构：

[1] University of Colorado Health Sciences Center,Department of Pharmaceutical Sciences, School of Pharmacy

[2] University of Colorado Health Sciences Center,Department of Neurosurgery, School of Medicine

[3] University of Colorado Health Sciences Center,Department of Anesthesiology, School of Medicine

[4] University of Colorado Health Sciences Center,Department of Neurosurgery, School of Medicine

[5] University of Denver Research Institute,Department of Pharmaceutical Sciences, School of Pharmacy

[6] University of Colorado Health Sciences Center,undefined

来源：

Pharmaceutical Research | 2001年 / 18卷

关键词：

ultrasound; hyperthermia; multi-drug resistance; MDR; P-glycoprotein; P-glycoprotein modulating agents; verapamil; anticancer drugs;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose. Localized hyperthermia has been shown previously to augment the cytotoxicity of some lipophilic anticancer drugs. Because many of the substrates for the multi-drug resistance (MDR) transporter P-glycoprotein (P-gp) are lipophilic in nature, studies were conducted to test the hypothesis that hyperthermia induced by ultrasound could also increase cellular uptake and cytotoxicity of P-gp substrates by P-gp-expressing cells.

引用

页码：1255 / 1261

页数：6

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