Glomerular CD8+ cells predict progression of childhood IgA nephropathy

被引：0

作者：

Toru Watanabe

H. Kawachi

Yohei Ikezumi

Toshio Yanagihara

Yoshihiko Oda

Fujio Shimizu

机构：

[1] Department of Cell Biology,

[2] Institute of Nephrology,undefined

[3] Faculty of Medicine,undefined

[4] Niigata University,undefined

[5] 1-757 Asahimachi-dori,undefined

[6] Niigata,undefined

[7] 951-8510,undefined

[8] Japan e-mail: kawachi@med.niigata-u.ac.jp Tel.: +81-25-2272160,undefined

[9] Fax: +81-25-2270770,undefined

[10] Department of Pediatrics,undefined

[11] Niigata City General Hospital,undefined

[12] Niigata,undefined

[13] Japan,undefined

[14] Department of Pediatrics,undefined

[15] Yoshida Hospital,undefined

[16] Japan,undefined

来源：

Pediatric Nephrology | 2001年 / 16卷

关键词：

Keywords T-lymphocytes; CD8+ cell; α-Smooth muscle actin; Transforming growth factor-β;

D O I：

暂无

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学科分类号：

摘要：

The aim of this study was to evaluate whether the infiltrating T-lymphocyte can be a predictor in the disease progression of IgA nephropathy (IgAN). Twenty children with IgAN, followed for more than 5 years, were divided into progressive (n=5) and non-progressive groups (n=15). We assessed glomerular and interstitial infiltration of T-lymphocytes (CD4+ and CD8+ cells) and expression of α-smooth muscle actin (α-SMA) and transforming growth factor- β (TGF- β) using an indirect immunofluorescence method on the renal biopsies. We analyzed their relationship to the degree of proteinuria, histological changes, and prognosis. The number of CD8+ cells in glomeruli and in interstitium was higher in the progressive group than in the non-progressive group. The glomerular α-SMA staining was more intensive in the progressive group than in the non-progressive group. Urinary protein and the degree of histological changes were also higher in the progressive group than in the non-progressive group. Among these markers, the number of glomerular CD8+ cells was the most apparent difference between the two groups. In conclusion, these results indicate that the number of glomerular CD8+ cells is the most sensitive predictor of disease progression in childhood IgAN.

引用

页码：561 / 567

页数：6