Engineered immune cells with nanomaterials to improve adoptive cell therapy

被引:0
作者
Na Yeon Kim
Ji-Ho Park
机构
[1] Korea Advanced Institute of Science and Technology (KAIST),Department of Bio and Brain Engineering, and KAIST Institute for Health Science and Technology
来源
Biomedical Engineering Letters | 2021年 / 11卷
关键词
Adoptive immunotherapy; Cancer; Immune cells; Nanoengineering; Targeting;
D O I
暂无
中图分类号
学科分类号
摘要
Cell-based cancer immunotherapy is mainly performed to re-stimulate or boost the anti-tumor immunity by leveraging the anti-tumoral functions of infused cells. Although conventional adoptive cell therapy with T cells and DC vaccines had potentiated the use of ex vivo engineered cells for cancer immunotherapy, these approaches had a low success rate and some off-target side effects. Recent developments on this intervention are adopting nanoengineering to overcome limitations imposed by the environment the therapeutic cells would be in and the natural characteristics of the cells; thus, enhancing the efficacy of therapies. For this purpose, T cells, NK cells, DCs, and macrophages are engineered to either maintain anti-tumoral phenotypes, target tumor efficiently, or improve the innate functionalities and viability.
引用
收藏
页码:183 / 195
页数:12
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