Cardiovascular effects of prostaglandin F2α and prostaglandin E2 in Atlantic cod (Gadus morhua)

被引：0

作者：

K.-O. Stensløkken

L. Sundin

G. Nilsson

机构：

[1] Division of General Physiology,

[2] Department of Biology,undefined

[3] University of Oslo,undefined

[4] PO Box 1051,undefined

[5] N-0316 Oslo,undefined

[6] Norway,undefined

[7] Department of Zoophysiology,undefined

[8] Göteborg University,undefined

[9] Box 463,undefined

[10] S-405 30 Göteborg,undefined

[11] Sweden,undefined

来源：

Journal of Comparative Physiology B | 2002年 / 172卷

关键词：

Prostaglandins Atlantic cod Gill Cardiovascular Vasoconstriction;

D O I：

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学科分类号：

摘要：

Little is known of the cardiovascular functions of prostaglandins in non-mammalian vertebrates. There are indications that prostaglandins may have a function in haemostasis by constricting blood vessels in filament arteries in the fish gill after injury. Our aim was to examine the cardiovascular effect of the prostaglandins F2α (PGF2α) and E2 (PGE2) with emphasis on branchial circulation. Intra-arterial injections of PGF2α (10, 40, 160, 400 nmol kg–1) in cod caused a dose-dependent increase in ventral aortic blood pressure, a reduction in cardiac output, and an increase in gill vascular resistance. A contraction of filament arteries was observed with in vivo microscopy only seconds after injection. PGF2α may therefore possibly be involved in a haemostatic vasoconstriction. In contrast, the most significant effects of PGE2 appeared to be on the heart. PGE2 also reduced dorsal aortic blood pressure.

引用

页码：363 / 369

页数：6