Montelukast in the Treatment of Allergic RhinitisAn Evidence-Based Review

被引：0
作者：
Anjuli Nayak
Ronald B. Langdon
机构：
[1] Sneeze,
[2] Wheeze & Itch Associates,undefined
[3] LLC,undefined
[4] Merck Research Laboratories,undefined
来源：
Drugs | 2007年 / 67卷
关键词：
Asthma; Allergic Rhinitis; Allergic Rhinitis; Fluticasone Propionate; Montelukast;
D O I：
暂无
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学科分类号：
摘要：
Cysteinyl-leukotrienes (CysLTs) are endogenous mediators of inflammation and play an important role in allergic airway disease by stimulating bronchoconstriction, mucus production, mucosal oedema and inflammation, airway infiltration by eosinophils, and dendritic cell maturation that prepares for future allergic response. Montelukast inhibits these actions by blocking type 1 CysLT receptors found on immunocytes, smooth muscle and endothelium in the respiratory mucosa. Initially developed as a treatment for asthma, montelukast has more recently found use in the treatment of allergic rhinitis (AR).
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页码：887 / 901
页数：14
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