Genome-wide analysis of protein-DNA interactions in living cells

被引：0
|
作者：
B Franklin Pugh
David S Gilmour
机构：
[1] Pennsylvania State University,Center for Gene Regulation, Department of Biochemistry and Molecular Biology
来源：
Genome Biology | / 2卷 / 4期
关键词：
Intergenic Region; Gene Expression Program; Consensus Binding Site; Arginine Side Chain; Additional Transcription Factor;
D O I：
10.1186/gb-2001-2-4-reviews1013
中图分类号：
学科分类号：
摘要：
Understanding the regulation of gene expression requires an analysis of gene-specific transcription factors. This review highlights recent work that uses protein-DNA crosslinking, immunoprecipitation and DNA microarrays to determine the binding sites for specific transcription factors throughout the yeast genome.
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