TH1 and TH2 cells: a historical perspective

被引:0
作者
Foo Y. Liew
机构
[1] University of Glasgow,Department of Immunology and Bacteriology
来源
Nature Reviews Immunology | 2002年 / 2卷
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摘要
Demonstration of the existence and functions of T helper (TH)1 and TH2 cells has had an enormous impact on basic and applied immunology. TH1 and TH2 cells have a crucial role in balancing the immune response. In this article, I attempt to trace the historical events contributing to the development of the TH1/TH2 concept, the current state of play, and briefly discuss the future prospects for the field.
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页码:55 / 60
页数:5
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共 187 条
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Seder RA(undefined)Uptake of microparticle-adsorbed protein antigen by bone marrow-derived dendritic cells results in up-regulation of interleukin-1 α and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation undefined undefined undefined-undefined
[83]  
Paul WE(undefined)Dendritic cells produce IL-12 and direct the development of T undefined undefined undefined-undefined
[84]  
Davis MM(undefined)1 cells from naive CD4 undefined undefined undefined-undefined
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Fazekas de St Groth B(undefined) T cells undefined undefined undefined-undefined
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Hosken NA(undefined)CD4 undefined undefined undefined-undefined
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Shibuya K(undefined), NK1.1 undefined undefined undefined-undefined
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Heath AW(undefined) T cells promptly produce interleukin 4 in response to undefined undefined undefined-undefined
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Murphy KM(undefined) challenge with anti-CD3 undefined undefined undefined-undefined
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O'Garra A(undefined)Mast cell lines produce lymphokines in response to cross-linkage of Fcɛ RI or to calcium ionophores undefined undefined undefined-undefined