TH1 and TH2 cells: a historical perspective

被引:0
作者
Foo Y. Liew
机构
[1] University of Glasgow,Department of Immunology and Bacteriology
来源
Nature Reviews Immunology | 2002年 / 2卷
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摘要
Demonstration of the existence and functions of T helper (TH)1 and TH2 cells has had an enormous impact on basic and applied immunology. TH1 and TH2 cells have a crucial role in balancing the immune response. In this article, I attempt to trace the historical events contributing to the development of the TH1/TH2 concept, the current state of play, and briefly discuss the future prospects for the field.
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页码:55 / 60
页数:5
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[1]  
Dennert G(1974)Evidence for non-identity of T killer and T helper cells sensitised to allogeneic cell antigens Nature 249 358-360
[2]  
Cantor H(1975)Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen J. Exp. Med. 141 1376-1389
[3]  
Boyse EA(1975)Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse Nature 253 219-220
[4]  
Kisielow P(1979)A T helper cell for anti-viral cytotoxic T-cell responses J. Exp. Med. 150 1277-1282
[5]  
Ashman RB(1971)Infectious immunological tolerance Immunology 21 903-914
[6]  
Mullbacher A(1974)Lack of a correlation between cell-mediated immunity to the carrier and the carrier-hapten helper effect J. Exp. Med. 139 779-784
[7]  
Gershon RK(1975)Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells J. Immunol. 114 1116-1125
[8]  
Kondo K(1975)Cellular cooperation during J. Immunol. 114 1394-1401
[9]  
Liew FY(1978) anti-hapten antibody responses. I. The effect of cell number on the response J. Exp. Med. 147 446-458
[10]  
Parish CR(1986)Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia J. Immunol. 136 2348-2357