Histone deacetylases and cancer

被引：0
作者：
M A Glozak
E Seto
机构：
[1] H. Lee Moffitt Cancer Center & Research Institute,
来源：
Oncogene | 2007年 / 26卷
关键词：
acetylation; deacetylation; cancer; HDAC; HDAC inhibitors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Histone deacetylases (HDACs) regulate the expression and activity of numerous proteins involved in both cancer initiation and cancer progression. By removal of acetyl groups from histones, HDACs create a non-permissive chromatin conformation that prevents the transcription of genes that encode proteins involved in tumorigenesis. In addition to histones, HDACs bind to and deacetylate a variety of other protein targets including transcription factors and other abundant cellular proteins implicated in control of cell growth, differentiation and apoptosis. This review provides a comprehensive examination of the transcriptional and post-translational mechanisms by which HDACs alter the expression and function of cancer-associated proteins and examines the general impact of HDAC activity in cancer.
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页码：5420 / 5432
页数：12
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