The inextricable link between atherosclerosis and prototypical inflammatory diseases rheumatoid arthritis and systemic lupus erythematosus

被引：0
作者：
Louise E Full
Cristina Ruisanchez
Claudia Monaco
机构：
[1] Imperial College,Kennedy Institute of Rheumatology Division, Faculty of Medicine
来源：
Arthritis Research & Therapy | / 11卷
关键词：
Rheumatoid Arthritis; Systemic Lupus Erythematosus; Rheumatoid Arthritis Patient; Systemic Lupus Erythematosus Patient; Coronary Artery Calcification;
D O I：
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学科分类号：
摘要：
The increased burden of cardiovascular disease in patients with rheumatoid arthritis and systemic lupus erythematosus has recently become the focus of intense investigation. Proatherogenic risk factors and dysregulated inflammation are the main culprits, leading to enhanced atherosclerosis in subgroups of patients with inflammatory diseases. Common molecular pathways shared by atherosclerosis and inflammatory disease may be involved. In this review we map the key determinants of the increased incidence of cardiovascular disease in patients with inflammatory diseases at each step of the atherogenesis.
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