Efficacy and tolerability of the dual 5α-reductase inhibitor, dutasteride, in the treatment of benign prostatic hyperplasia in African-American men

被引：0
作者：
C G Roehrborn
P Ray
机构：
[1] The University of Texas Southwestern Medical Center at Dallas,Department of Urology
[2] Cook County Hospital,Division of Urology
来源：
Prostate Cancer and Prostatic Diseases | 2006年 / 9卷
关键词：
benign prostatic hyperplasia; African-American men; dutasteride;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The efficacy and tolerability of dutasteride (0.5 mg daily for 2 years) in African-Americans (n=161), compared with Caucasians (n=3961), was assessed in a post hoc analysis of data from three Phase III clinical trials. Dutasteride significantly reduced serum dihydrotestosterone levels by >90% and significantly improved subjective (symptom score) and objective (prostate volume, peak urinary flow rate, risk of benign prostatic hyperplasia-related surgery and acute urinary retention) outcomes in both African-Americans and Caucasians. For all efficacy measures, there was no statistically significant treatment-by-race interaction and dutasteride was well tolerated in both racial groups. Therefore, dutasteride demonstrated similar efficacy and safety profiles in African-Americans and Caucasians.
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页码：432 / 438
页数：6
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