Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry

被引：0
作者：
S Kühn
F Musso
A Mobascher
T Warbrick
G Winterer
J Gallinat
机构：
[1] Charité University Medicine,Department of Experimental Psychology
[2] St Hedwig-Krankenhaus,Department of Psychiatry
[3] Clinic for Psychiatry and Psychotherapy,Department of Psychiatry
[4] Ghent Institute for Functional and Metabolic Imaging,undefined
[5] University of Düsseldorf,undefined
[6] University of Mainz,undefined
[7] Institute of Neurosciences and Medicine,undefined
[8] Helmholtz Research Centre Jülich,undefined
[9] Cologne Center for Genomics,undefined
[10] University of Cologne,undefined
来源：
Translational Psychiatry | 2012年 / 2卷
关键词：
CA1; CA2/3; FreeSurfer; hippocampus; schizophrenia; volumetry;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2/3 as well as CA1 volume was found on high-resolution magnetic resonance images. Our observation opens the gate for advanced investigation of the commonly reported hippocampal abnormalities in schizophrenia in terms of specific subfields.
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页码：e127 / e127
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