Aging of the hematopoietic stem cells niche

被引：0
|
作者：
Ayako Nakamura-Ishizu
Toshio Suda
机构：
[1] Keio University,Department of Cell Differentiation, The Sakaguchi Laboratory
来源：
International Journal of Hematology | 2014年 / 100卷
关键词：
Aging; Hematopoietic stem cells; Niche; Bone marrow;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. We review here the age-related changes that the BM microenvironment exerts on HSCs.
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页码：317 / 325
页数：8
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