Human gut microbes impact host serum metabolome and insulin sensitivity

被引：0

作者：

Helle Krogh Pedersen

Valborg Gudmundsdottir

Henrik Bjørn Nielsen

Tuulia Hyotylainen

Trine Nielsen

Benjamin A. H. Jensen

Kristoffer Forslund

Falk Hildebrand

Edi Prifti

Gwen Falony

Emmanuelle Le Chatelier

Florence Levenez

Joel Doré

Ismo Mattila

Damian R. Plichta

Päivi Pöhö

Lars I. Hellgren

Manimozhiyan Arumugam

Shinichi Sunagawa

Sara Vieira-Silva

Torben Jørgensen

Jacob Bak Holm

Kajetan Trošt

MetaHIT Consortium

Karsten Kristiansen

Susanne Brix

Jeroen Raes

Jun Wang

Torben Hansen

Peer Bork

Søren Brunak

Matej Oresic

S. Dusko Ehrlich

Oluf Pedersen

机构：

[1] Center for Biological Sequence Analysis,Department of Biology

[2] Dept. of Systems Biology,Department of Bioscience Engineering

[3] Technical University of Denmark,Department of Microbiology and Immunology

[4] University of Örebro,Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology

[5] Turku Centre for Biotechnology,Department of Bioinformatics

[6] University of Turku and Åbo Akademi University,undefined

[7] VTT Technical Research Centre of Finland,undefined

[8] The Novo Nordisk Foundation Center for Basic Metabolic Research,undefined

[9] Faculty of Health and Medical Sciences,undefined

[10] University of Copenhagen,undefined

[11] Laboratory of Genomics and Molecular Biomedicine,undefined

[12] University of Copenhagen,undefined

[13] European Molecular Biology Laboratory,undefined

[14] Vrije Universiteit Brussel,undefined

[15] Center for the Biology of Disease,undefined

[16] VIB,undefined

[17] MGP MetaGénoPolis,undefined

[18] INRA,undefined

[19] Université Paris-Saclay,undefined

[20] Institute of Cardiometabolism and Nutrition (ICAN),undefined

[21] Rega Institute,undefined

[22] Micalis Institute,undefined

[23] INRA,undefined

[24] AgroParisTech,undefined

[25] Université Paris-Saclay,undefined

[26] Steno Diabetes Center,undefined

[27] Faculty of Pharmacy,undefined

[28] University of Helsinki,undefined

[29] Institute of Microbiology,undefined

[30] Faculty of Health and Medical Sciences,undefined

[31] University of Copenhagen,undefined

[32] Research Centre for Prevention and Health,undefined

[33] Centre for Health,undefined

[34] Capital region,undefined

[35] Glostrup Hospital,undefined

[36] BGI-Shenzhen,undefined

[37] Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders,undefined

[38] King Abdulaziz University,undefined

[39] Macau University of Science and Technology,undefined

[40] University of Hong Kong,undefined

[41] Faculty of Health Sciences,undefined

[42] University of Southern Denmark,undefined

[43] Molecular Medicine Partnership Unit,undefined

[44] University of Heidelberg and European Molecular Biology Laboratory,undefined

[45] Max Delbrück Centre for Molecular Medicine,undefined

[46] University of Wuerzburg,undefined

[47] Novo Nordisk Foundation Center for Protein Research,undefined

[48] Disease Systems Biology,undefined

[49] Faculty of Health and Medical Sciences,undefined

[50] University of Copenhagen,undefined

来源：

Nature | 2016年 / 535卷

关键词：

D O I：

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学科分类号：

摘要：

Increased potential for branched-chain amino acid and lipopolysaccharide biosynthesis in the gut microbiome of insulin-resistant individuals suggests that changes in the serum metabolome induced by dysbiosis, and driven by only a handful of species, contribute to the development of diabetes.

引用

页码：376 / 381

页数：5

共 50 条

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