机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Giuseppe Di Fede
Marcella Catania
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Marcella Catania
Emanuela Maderna
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Emanuela Maderna
Roberta Ghidoni
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Roberta Ghidoni
Luisa Benussi
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Luisa Benussi
Elisa Tonoli
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Elisa Tonoli
Giorgio Giaccone
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Giorgio Giaccone
Fabio Moda
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Fabio Moda
Anna Paterlini
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Anna Paterlini
Ilaria Campagnani
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Ilaria Campagnani
Stefano Sorrentino
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Stefano Sorrentino
Laura Colombo
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Laura Colombo
Adriana Kubis
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Adriana Kubis
Edoardo Bistaffa
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Edoardo Bistaffa
Bernardino Ghetti
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Bernardino Ghetti
Fabrizio Tagliavini
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机构:IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
Fabrizio Tagliavini
机构:
[1] IRCCS Foundation “Carlo Besta” Neurological Institute,Department of Molecular Biochemistry and Pharmacology
[2] Molecular Markers Laboratory,Department of Toxicology
[3] IRCCS Istituto Centro San Giovanni di Dio - Fatebenefratelli,Department of Pathology and Laboratory Medicine
[4] IRCCS Istituto di Ricerche Farmacologiche “Mario Negri”,undefined
[5] Wroclaw Medical University,undefined
[6] Indiana University,undefined
[7] Indianapolis,undefined
来源:
Scientific Reports
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8卷
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摘要:
Protein misfolding and aggregation is a central feature of several neurodegenerative disorders including Alzheimer’s disease (AD), in which assemblies of amyloid β (Aβ) peptides accumulate in the brain in the form of parenchymal and/or vascular amyloid. A widely accepted concept is that AD is characterized by distinct clinical and neuropathological phenotypes. Recent studies revealed that Aβ assemblies might have structural differences among AD brains and that such pleomorphic assemblies can correlate with distinct disease phenotypes. We found that in both sporadic and inherited forms of AD, amyloid aggregates differ in the biochemical composition of Aβ species. These differences affect the physicochemical properties of Aβ assemblies including aggregation kinetics, resistance to degradation by proteases and seeding ability. Aβ-amyloidosis can be induced and propagated in animal models by inoculation of brain extracts containing aggregated Aβ. We found that brain homogenates from AD patients with different molecular profiles of Aβ are able to induce distinct patterns of Aβ-amyloidosis when injected into mice. Overall these data suggest that the assembly of mixtures of Aβ peptides into different Aβ seeds leads to the formation of distinct subtypes of amyloid having distinctive physicochemical and biological properties which result in the generation of distinct AD molecular subgroups.
机构:
Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Neuropathol & Neurosci, Tokyo 1130033, JapanUniv Tokyo, Grad Sch Pharmaceut Sci, Dept Neuropathol & Neurosci, Tokyo 1130033, Japan